10 Best Duo Synthesis Skills To Prioritize in Metaphor: ReFantazio
Metaphor ReFantazio

10 Best Duo Synthesis Skills To Prioritize in Metaphor: ReFantazio

The latest RPG from Atlus, Metaphor: ReFantazio, brings a unique twist to the familiar mechanics of game lore and factions, blending rich storytelling with innovative gameplay systems. A key highlight is the Metaphor ReFantazio skill synthesis system, which enables players to combine the abilities of various Archetypes to unlock potent duo synthesis skills. These abilities are crucial for creating versatile party compositions and tackling the game’s most challenging encounters.

In this guide, we break down the 10 best duo synthesis skills that you should prioritize to ensure victory in the world of Metaphor: ReFantazio.

What Are Duo Synthesis Skills in Metaphor ReFantazio?

Duo synthesis skills are unique abilities unlocked by pairing complementary Archetypes within your party. These Archetypes, tied to different game lore and factions, represent distinct roles, such as Healer, Knight, or Summoner. By leveling up specific Archetype lineages and pairing them with suitable allies, you unlock powerful skills that can turn the tide of battle.

Mastering the Metaphor ReFantazio’s skill synthesis system involves not just understanding these skills but also strategically planning your party composition for maximum synergy.

10. Wild Bore

  • Archetype: Berserker (Destroyer)
  • Ally Requirement: Gunner, Faker, or Summoner
  • Effect: Heavy pierce damage to a single enemy and reduces their attack for three turns.

Wild Bore stands out as a key offensive ability in the Metaphor ReFantazio skill synthesis system. The combination of high damage and attack reduction makes it especially effective against bosses, neutralizing their power while exploiting their weaknesses.

9. Hadean Icecrag

  • Archetype: Summoner (Devil Summoner)
  • Ally Requirement: Seeker, Mage, or Healer
  • Effect: Extreme ice damage to all enemies.

Ideal for crowd control, Hadean Icecrag’s wide AoE ensures swift elimination of ice-weak foes. However, players must carefully assess the game lore and factions, as certain enemies may nullify or repel ice damage, potentially turning this skill against its user.


8. Megidolaon

  • Archetype: Commander (Warlord)
  • Ally Requirement: Gunner, Faker, or Summoner
  • Effect: Almighty damage to all enemies.

Megidolaon’s Almighty damage bypasses enemy resistances, making it one of the most reliable offensive tools in the Metaphor ReFantazio’s skill synthesis arsenal. This skill is invaluable during encounters where elemental damage is rendered ineffective.

7. Medicall

  • Archetype: Healer (Cleric)
  • Ally Requirement: Knight, Healer, or Commander
  • Effect: Fully heals all allies.

A staple in defensive strategies, Medicall ensures your party can recover from heavy damage in critical moments. This skill highlights the importance of game lore and factions, as knowing enemy attack patterns will help determine when to deploy them.


6. Crimson Moon Sword Art

  • Archetype: Warrior (Samurai)
  • Ally Requirement: Warrior, Brawler, or Berserker
  • Effect: Severe slash damage to all enemies with a chance to charm.

Crimson Moon Sword Art provides a devastating combination of damage and utility. Charm can disrupt enemy formations, causing foes to attack their own allies, which aligns perfectly with the strategic depth of Metaphor ReFantazio skill synthesis.

5. All Reset

  • Archetype: Merchant (Tycoon)
  • Ally Requirement: Thief, Faker, or Merchant
  • Effect: Removes all buffs from enemies.

As the story progresses, bosses tied to game lore and factions frequently deploy powerful buffs. All Reset counters these strategies, ensuring your team retains the upper hand in battle.


4. Ultimate Guard

  • Archetype: Knight (Royal Knight)
  • Ally Requirement: Knight, Healer, or Commander
  • Effect: Grants a barrier that negates one non-Almighty attack for all allies.

Ultimate Guard is a high-cost skill that offers unparalleled protection, negating devastating attacks. It’s a lifesaver in encounters against enemies with unpredictable and powerful abilities.

3. Trial of the Seeker

  • Archetype: Seeker (Soul Hacker)
  • Ally Requirement: Warrior, Thief, or Masked Dancer
  • Effect: Almighty damage to all enemies and restores MP per hit.

Trial of the Seeker combines offense with resource management, making it a cornerstone of the Metaphor ReFantazio’s skill synthesis system. Its ability to recover MP allows for sustained aggression over extended battles.


2. Masquerade Charge

  • Archetype: Masked Dancer (Royal Masked Dancer)
  • Ally Requirement: Gunner, Masked Dancer, or Berserker
  • Effect: Greatly boosts physical attack for all allies, once per fight.

Masquerade Charge is essential for teams focused on physical damage. Though limited to one use per fight, its effect can be the difference between victory and defeat, particularly against high-health bosses tied to factions and game lore.

1. Deadly Eraser

  • Archetype: Berserker (Destroyer)
  • Ally Requirement: Brawler, Merchant, or Summoner
  • Effect: Severe Almighty damage to a single enemy and removes most buffs and repel.

Deadly Eraser’s combination of high damage and buff removal makes it one of the most versatile skills in the game. Its relatively low MP cost allows for repeated use, cementing its place as a priority in the Metaphor ReFantazio skill synthesis system.

Tips for Mastering Duo Synthesis Skills

  1. Understand Archetype Lineages: Each Archetype is tied to distinct game lore and factions. Familiarize yourself with their strengths and weaknesses to build a balanced party.
  2. Level Strategically: Focus on Archetypes that complement each other to unlock these skills sooner.
  3. Study Enemy Patterns: Many duo synthesis skills exploit enemy weaknesses. Pay attention to resistances and repels during battle.

Final Thoughts

The Metaphor ReFantazio skill synthesis system is a testament to the game’s depth, combining strategic combat with engaging game lore and factions. By mastering these 10 duo synthesis skills, you’ll gain an edge in battles, ensuring your team is ready for any challenge. Dive into this captivating world, experiment with combinations, and watch your party’s synergy soar.


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